A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions

@inproceedings{Murray2015AHM,
  title={A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions},
  author={Thomas D. Murray and Artem Y. Lyubimov and Craig M. Ogata and Huy Vo and Monarin Uervirojnangkoorn and Axel T Brunger and James M Berger},
  booktitle={Acta crystallographica. Section D, Biological crystallography},
  year={2015}
}
Microcrystals present a significant impediment to the determination of macromolecular structures by X-ray diffraction methods. Although microfocus synchrotron beamlines and X-ray free-electron lasers (XFELs) can enable the collection of interpretable diffraction data from microcrystals, there is a need for efficient methods of harvesting small volumes (<2 µl) of microcrystals grown under common laboratory formats and delivering them to an X-ray beam source under native growth conditions. One… CONTINUE READING
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