A high throughput screen to identify secreted and transmembrane proteins involved in Drosophila embryogenesis.

@article{Kopczynski1998AHT,
  title={A high throughput screen to identify secreted and transmembrane proteins involved in Drosophila embryogenesis.},
  author={Casey C. Kopczynski and Jasprien N Noordermeer and Thomas L. Serano and Wei Chen and J. David Pendleton and Suzanne K. Lewis and Corey S. Goodman and Gerald M. Rubin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 17},
  pages={9973-8}
}
Secreted and transmembrane proteins play an essential role in intercellular communication during the development of multicellular organisms. Because only a small number of these genes have been characterized, we developed a screen for genes encoding extracellular proteins that are differentially expressed during Drosophila embryogenesis. Our approach utilizes a new method for screening large numbers of cDNAs by whole-embryo in situ hybridization. The cDNA library for the screen was prepared… CONTINUE READING

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