A high throughput molecular force assay for protein-DNA interactions.

  title={A high throughput molecular force assay for protein-DNA interactions.},
  author={Philip M. D. Severin and Dominik Ho and Hermann Eduard Gaub},
  journal={Lab on a chip},
  volume={11 5},
An accurate and genome-wide characterization of protein-DNA interactions such as transcription factor binding is of utmost importance for modern biology. Powerful screening methods emerged. But the vast majority of these techniques depend on special labels or markers against the ligand of interest and moreover most of them are not suitable for detecting low-affinity binders. In this article a molecular force assay is described based on measuring comparative unbinding forces of biomolecules for… CONTINUE READING
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This journal is ª The Royal Society of Chemistry

  • Lab Chip
  • This journal is ª The Royal Society of Chemistry
  • 2011
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  • 2011

Chem. Soc. Rev

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Anal. Chem

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Lab Chip

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J. Phys.: Condens. Matter

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Nat. Biotechnol

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