A high-throughput microfluidic approach for 1000-fold leukocyte reduction of platelet-rich plasma

@inproceedings{Xia2016AHM,
  title={A high-throughput microfluidic approach for 1000-fold leukocyte reduction of platelet-rich plasma},
  author={Hui Xia and Briony C. Strachan and Sean C Gifford and Sergey S Shevkoplyas},
  booktitle={Scientific reports},
  year={2016}
}
Leukocyte reduction of donated blood products substantially reduces the risk of a number of transfusion-related complications. Current 'leukoreduction' filters operate by trapping leukocytes within specialized filtration material, while allowing desired blood components to pass through. However, the continuous release of inflammatory cytokines from the retained leukocytes, as well as the potential for platelet activation and clogging, are significant drawbacks of conventional 'dead end… CONTINUE READING