A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines

@article{Flobak2019AHD,
  title={A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines},
  author={{\AA}smund Flobak and Barbara Niederdorfer and Vu To Nakstad and Liv Thommesen and Geir Klinkenberg and Astrid L{\ae}greid},
  journal={Scientific Data},
  year={2019},
  volume={6}
}
AbstractWhile there is a high interest in drug combinations in cancer therapy, openly accessible datasets for drug combination responses are sparse. Here we present a dataset comprising 171 pairwise combinations of 19 individual drugs targeting signal transduction mechanisms across eight cancer cell lines, where the effect of each drug and drug combination is reported as cell viability assessed by metabolic activity. Drugs are chosen by their capacity to specifically interfere with well-known… 
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