A high-throughput de novo sequencing approach for shotgun proteomics using high-resolution tandem mass spectrometry

@inproceedings{Pan2009AHD,
  title={A high-throughput de novo sequencing approach for shotgun proteomics using high-resolution tandem mass spectrometry},
  author={Chongle Pan and Byung-Hoon Park and William H. McDonald and Patricia A. Carey and Jillian F. Banfield and Nathan Verberkmoes and Robert L. Hettich and Nagiza F. Samatova},
  booktitle={BMC Bioinformatics},
  year={2009}
}
High-resolution tandem mass spectra can now be readily acquired with hybrid instruments, such as LTQ-Orbitrap and LTQ-FT, in high-throughput shotgun proteomics workflows. The improved spectral quality enables more accurate de novo sequencing for identification of post-translational modifications and amino acid polymorphisms. In this study, a new de novo sequencing algorithm, called Vonode, has been developed specifically for analysis of such high-resolution tandem mass spectra. To fully exploit… CONTINUE READING
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