A high-resolution survey of the effects of 5-aza-dC treatment on the chromatin state of MCF7 breast cancer cells [Engineering in Genomics]

@article{Weil2008AHS,
  title={A high-resolution survey of the effects of 5-aza-dC treatment on the chromatin state of MCF7 breast cancer cells [Engineering in Genomics]},
  author={Michael C. Weil and Cristi L. Galindo and Harold E. Garner},
  journal={IEEE Engineering in Medicine and Biology Magazine},
  year={2008},
  volume={27},
  pages={86-100}
}
E pigenetically mediated transcriptional silencing events involving DNA methylation have been strongly associated with cancer development. As a result, several studies have been conducted that examine the transcriptional effects of epigeneticmodifying drugs, such as the DNA methylation inhibitor 5-aza-dC, on cancer cells. However, the effects of these drugs on the chromatin state have received much less attention. In this study, we performed a global high-resolution survey of the chromatin… CONTINUE READING

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