A high pressure liquid chromatographic determination of p-chlorophenoxyisobutyric acid and its comparison to a GLC and an ultra violet spectrophotometric method.

@article{Robinson1978AHP,
  title={A high pressure liquid chromatographic determination of p-chlorophenoxyisobutyric acid and its comparison to a GLC and an ultra violet spectrophotometric method.},
  author={William T. Robinson and L Cosyns and Michael Kraml},
  journal={Clinical biochemistry},
  year={1978},
  volume={11 5},
  pages={
          214-7
        }
}
5 Citations
METABOLIC DISPOSITION OF CLOFIBRATE
TLDR
Although Clofibrate is an enzyme inducer in rats, there is no evidence that it induces liver microsomal enzymes in man or in monkeys, and the studies reported to date imply that the enhanced anticoagulant activity of warfarin in the presence of Cl ofibrates is the result of a pharmacodynamic rather than pharmacokinetic interaction.

References

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Determination of clofibrate in biological fluids by thin-layer and gas-liquid chromatography.
TLDR
A specific and sensitive method is described for the detection of clofibrate in biological fluids, which is more time-consuming than other available techniques, but offers advantages for accurate studies of cl ofibrate metabolism.
A GLC method for estimation of chlorophenoxyisobutyric acid in plasma. Pharmacokinetics of a single oral dose of clofibrate in man
TLDR
The GLC method has been employed to study the pharmacokinetics of chlorophenoxyisobutyric acid in man after oral ingestion of a single dose of clofibrate, and did not interfere with the analysis, but it could not be employed in the presence of salicylates.
Quantitative gas-chromatographic flame-ionization method for p-chlorophenoxyisobutyric acid in human serum and saliva.
TLDR
Serum and salivary concentrations of I as determined by the gas-chromatographic method were used to calculate the unbound fraction of drug in human serum, which can be used to monitor therapy in patients with renal disease, where drug toxicity may arise from high concentrations of unbound I.
Serum clofibrate concentrations in patients on continuous medication.
Total and unbound 2-(chlorophenoxy)-2-methyl propionic acid (CPIB) concentrations were measured in serum samples taken from patients on continuous clofibrate medication, over a 5- to 6-hour period dur
Quantitative gas chromatographic determination of clofibrinic acid in plasma
  • A. Berlin
  • Medicine
    The Journal of pharmacy and pharmacology
  • 1975
BODEM, G. & CHIDSEY, C. A. (1972). Clin. Chem., 18, 363-365. BODEM, G. & CHIDSEY, C. A. (1973). Clin. Pharmac. Ther., 14, 26-29. FITZGERALD, J. D. & SCALES, B. (1968). Znt. Z . Klin. Pharmak. Ther.,
Clofibrate and clofibric acid: comparison of the metabolic disposition in rats and dogs.
TLDR
The results demonstrate that clofibric acid and clofibrate are metabolically and pharmacologically equivalent in rats, but not in dogs.
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