A high-performance liquid chromatographic assay for the determination of desbutylhalofantrine enantiomers in rat plasma.

@article{Brocks2001AHL,
  title={A high-performance liquid chromatographic assay for the determination of desbutylhalofantrine enantiomers in rat plasma.},
  author={Dion R. Brocks},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2001},
  volume={4 1},
  pages={24-31}
}
  • Dion R. Brocks
  • Published 2001 in
    Journal of pharmacy & pharmaceutical sciences : a…
PURPOSE To develop a stereoselective high performance liquid chromatographic assay for determination of desbutylhalofantrine (DHF) enantiomers in rat plasma. METHODS After protein precipitation of 100 microL of rat plasma, racemic DHF and internal standard (quinidine sulfate) were extracted into hexane in the presence of pH 8 phosphate buffer. After transfer and evaporation of the hexane, the residue was derivatized using 0.25 M (+)-di-O-acetyl-L-tartaric acid anhydride at 4 degrees C. After… CONTINUE READING
2 Citations
14 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 14 references

Stereospecific high performance liquid chromatographic (HPLC) analysis of halofantrine enantiomers in rat plasma

  • J. W. Toni, D. R. Brocks
  • Pharm Res,
  • 1997
1 Excerpt

Clinical pharmacokinetics of halofantrine

  • J. Karbwang, K. Na Bangchang
  • Clin. Pharmacokin
  • 1994
1 Excerpt

Cardiac effects of antimalarial treatment with halofantrine

  • F. Nosten, P. O. ter Kuile, +4 authors N. J. White
  • Lancet, 341:1054-1056,
  • 1993
1 Excerpt

Similar Papers

Loading similar papers…