A high observed substitution rate in the human mitochondrial DNA control region

@article{Parsons1997AHO,
  title={A high observed substitution rate in the human mitochondrial DNA control region},
  author={T. Parsons and D. Muniec and K. Sullivan and Nicola Woodyatt and R. Alliston-Greiner and M. Wilson and D. Berry and K. A. Holland and V. Weedn and P. Gill and M. Holland},
  journal={Nature Genetics},
  year={1997},
  volume={15},
  pages={363-368}
}
The rate and pattern of sequence substitutions in the mitochondrial DNA (mtDNA) control region (CR) is of central importance to studies of human evolution and to forensic identity testing. Here, we report a direct measurement of the intergenerational substitution rate in the human CR. We compared DNA sequences of two CR hypervariable segments from close maternal relatives, from 134 independent mtDNA lineages spanning 327 generational events. Ten substitutions were observed, resulting in an… Expand
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The mutation rate in the human mtDNA control region.
Explaining the Imperfection of the Molecular Clock of Hominid Mitochondria
Mutation patterns of mtDNA: Empirical inferences for the coding region
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