A high observed substitution rate in the human mitochondrial DNA control region

@article{Parsons1997AHO,
  title={A high observed substitution rate in the human mitochondrial DNA control region},
  author={Thomas J. Parsons and David Muniec and Kevin M. Sullivan and Nicola Woodyatt and R. Alliston-Greiner and Mark R. Wilson and Dianna L. Berry and Koren A. Holland and Victor W. Weedn and Peter Gill and Mitchell M. Holland},
  journal={Nature Genetics},
  year={1997},
  volume={15},
  pages={363-368}
}
The rate and pattern of sequence substitutions in the mitochondrial DNA (mtDNA) control region (CR) is of central importance to studies of human evolution and to forensic identity testing. Here, we report a direct measurement of the intergenerational substitution rate in the human CR. We compared DNA sequences of two CR hypervariable segments from close maternal relatives, from 134 independent mtDNA lineages spanning 327 generational events. Ten substitutions were observed, resulting in an… 
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