A high menaquinone intake reduces the incidence of coronary heart disease.
@article{Gast2009AHM, title={A high menaquinone intake reduces the incidence of coronary heart disease.}, author={Gerrie-Cor M. Gast and Nicole M. de Roos and Ivonne Sluijs and Michiel L. Bots and Joline W. J. Beulens and Johanna Marianna Geleijnse and Jacqueline C. M. Witteman and Diederick E. Grobbee and P. H. M. Peeters and Y. T. van der Schouw}, journal={Nutrition, metabolism, and cardiovascular diseases : NMCD}, year={2009}, volume={19 7}, pages={ 504-10 } }
254 Citations
Intake of Dietary Phylloquinone and Menaquinones and Risk of Stroke
- MedicineJournal of the American Heart Association
- 2013
Neither dietary phylloquinone nor dietary menaquinones intake were associated with stroke risk in a prospective cohort of 35 476 healthy subjects.
Vitamin K2 (menaquinone) Supplementation and its Benefits in Cardiovascular Disease, Osteoporosis, and Cancer
- Medicine, Biology
- 2016
The authors conclude that menaquinone supplementation has been shown to improve carboxylation of osteocalcin and matrix-Gla protein to their active forms, two proteins that possess important roles in calcium distribution.
Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study
- MedicineJournal of the American Heart Association
- 2021
Risk of ASCVD was inversely associated with diets high in vitamin K1 or K2, despite very different dietary sources, highlighting the potential importance of vitamin K for ASCVD prevention.
Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease.
- Medicine, BiologyMaturitas
- 2014
Association of dietary vitamin K and risk of coronary heart disease in middle-age adults: the Hordaland Health Study Cohort
- MedicineBMJ Open
- 2020
A higher intake of Vitamin K2 was associated with lower risk of CHD, while there was no association between intake of vitamin K1 and CHD.
Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis
- MedicineEuropean Journal of Nutrition
- 2019
The findings showed that higher dietary vitamin K consumption was associated with a moderately lower risk of CHD, and higher plasma dp-ucMGP concentration, but not total circulating osteocalcin, wasassociated with increased risks of all-cause and CVD mortality.
Effect of Menaquinone-7 (vitamin K2) on vascular elasticity in healthy subjects: results from a one-year study
- MedicineVascular Diseases and Therapeutics
- 2020
High vitamin K intake decreased age-related vascular stiffening and was most obvious in women with poor vitamin K status and were statistically significant after one year of treatment.
Association Between Vitamin K and the Metabolic Syndrome: A 10-Year Follow-Up Study in Adults.
- MedicineThe Journal of clinical endocrinology and metabolism
- 2015
It is shown that a high intake of menaquinones and high vitamin K status are associated with a lower occurrence of MetS, mainly driven by relations with lower triacylglycerol concentrations for menaquinone and lower waist circumference for vitamin Kstatus.
References
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Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women
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The data suggest that high phylloquinone intake may be a marker for low CHD risk, rather than intake of the nutrient itself, which might account for all or part of the weak association.
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The observed differences between K1 and MK-4 with respect to inhibition of arterial calcification may be explained by both differences in their tissue bioavailability and cofactor utilization in the reductase/carboxylase reaction.
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Vitamin K, discovered in the 1930s, functions as cofactor for the posttranslational carboxylation of glutamate residues. Gammacarboxy glutamic acid (Gla)-residues were first identified in prothrombin…
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The only known function of vitamin K in mammals is that it serves as a cofactor for the endoplasmic enzyme gamma-glutamyl carboxylase, where it promotes the post-translational conversion of selective protein-bound glutamate residues into gamma-carboxy glutamate (Gla).
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Abstract A provisional table on the vitamin K 1 (phylloquinone) content of foods was compiled in response to the expressed need for tabulated data by the public and professionals in medicine,…
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The first cycle of EPIC-Heart analyses will assess associations of coronary mortality with several prominent dietary hypotheses and with established cardiovascular risk factors, and will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors.