A high incidence of polymorphic CYP2C19 variants in archival blood samples from Papua New Guinea

@inproceedings{Hsu2008AHI,
  title={A high incidence of polymorphic CYP2C19 variants in archival blood samples from Papua New Guinea},
  author={Huai-Ling Hsu and Kathryn J Woad and D. Graeme Woodfield and Nuala Ann Helsby},
  booktitle={Human Genomics},
  year={2008}
}
There is considerable inter-ethnic variability in the incidence of CYP2C19 genetic poor metabolisers (var/var). About 3 per cent of Caucasians are CYP2C19 var/var. By contrast, an extremely high incidence (70 per cent) is observed in the Melanesian island of Vanuatu. The colonisation of the Pacific Islands is believed to have involved migration through Papua New Guinea (PNG), and hence a high incidence may also be expected in this population. The reported incidence in PNG was only 36 per cent… CONTINUE READING

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