A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma.

@article{Ross2014AHF,
  title={A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma.},
  author={Jeffrey S. Ross and Kai Wang and Laurie M Gay and Rami N Al-Rohil and Tipu Nazeer and Christine E. Sheehan and Timothy A. Jennings and Geoff A. Otto and Amy E Donahue and Jie He and G. M. Palmer and Siraj M Ali and Michelle K. Nahas and Geneva Young and Elaine Labrecque and Garrett M. Frampton and Rachel L. Erlich and John A. Curran and Kristina W Brennan and Sean R. Downing and Roman Yelensky and Doron Lipson and Matthew Hawryluk and Vincent A. Miller and Philip J. Stephens},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2014},
  volume={20 1},
  pages={68-75}
}
PURPOSE Micropapillary urothelial carcinoma (MPUC) is a rare and aggressive form of bladder cancer. We conducted genomic analyses [next-generation sequencing (NGS)] of MPUC and non-micropapillary urothelial bladder carcinomas (non-MPUC) to characterize the genomic landscape and identify targeted treatment options. EXPERIMENTAL DESIGN DNA was extracted from 40 μm of formalin-fixed paraffin-embedded sections from 15 MPUC and 64 non-MPUC tumors. Sequencing (NGS) was performed on hybridization… CONTINUE READING