A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers

@article{Cuevas2000AHD,
  title={A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers},
  author={Ada M. Cuevas and Viviana Guasch and Oscar Castillo and Ver{\'o}nica Irribarra and Claudio Mizon and Alejandra San Martin and Pablo Strobel and Druso D P{\'e}rez and Alfredo M. Germain and Federico M Leighton},
  journal={Lipids},
  year={2000},
  volume={35},
  pages={143-148}
}
Endothelial dysfunction is associated with atherogenesis and oxidative stress in humans. In rat and rabbit blood vessels, wine polyphenol antioxidants induce vascular relaxationin vitro through the NO-cGMP pathway. To assess the effect of a regular high-fat diet (HFD) and moderate red wine consumption on endothelial function (EF), a study was performed in healthy male volunteers. EF was measured as flow-mediated dilatation of the brachial artery, employing high-resolution ultrasound after an… CONTINUE READING