A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer

@article{Jiang2004AHE,
  title={A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer},
  author={Yixing Jiang and Liwei Wang and Weida Gong and Daoyan Wei and Xiangdong Le and James C. Yao and Jaffer A. Ajani and James L Abbruzzese and Suyun Huang and Keping Xie},
  journal={Clinical & Experimental Metastasis},
  year={2004},
  volume={21},
  pages={755-764}
}
Insulin-like growth factor I receptor (IGF-IR) is critical to cell survival and growth and altered IGF-IR expression is found in many human cancers. However, its expression and potential role in gastric cancer development and progression has not been explored. The IGF-IR expression level was determined via immunohistochemistry in primary tumor and lymph node metastasis of 86 cases of resected gastric cancer. Relationships of IGF-IR expression with transcription factor Sp1 expression and… CONTINUE READING

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Patients with lymph node metastases had strong expression of IGF - IR in both primary and metastatic tumor cells .
Patients with lymph node metastases had strong expression of IGF - IR in both primary and metastatic tumor cells .
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