A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects.

@article{Cate2010AHD,
  title={A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects.},
  author={Thomas R. Cate and Yolanda Rayford and Diane Ni{\~n}o and Patricia L. Winokur and Rebecca A Brady and Robert B. Belshe and Wilbur H Chen and Robert L. Atmar and Robert B. Couch},
  journal={Vaccine},
  year={2010},
  volume={28 9},
  pages={2076-9}
}
Antibody to the neuraminidase (NA) antigen of influenza viruses has been shown to correlate with immunity to influenza in humans and animal models. In a previous report, we showed that an inactivated influenza vaccine containing 60microg of the hemagglutinin (HA) of each strain induced significantly more serum anti-HA antibody among elderly persons than did the standard vaccine containing 15microg of the HA of each component. We developed a lectin-based assay for anti-NA antibody and used it to… CONTINUE READING

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