A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.

@article{Coon2007AHW,
  title={A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.},
  author={Keith D. Coon and Amanda J. Myers and David W. Craig and Jennifer A. Webster and John V. Pearson and Diane Hu Lince and Victoria Zismann and Thomas Gerald Beach and Doris Leung and Leslie A Bryden and Rebecca F. Halperin and Lauren E Marlowe and Mona M Kaleem and Douglas G. Walker and Rivka G. Ravid and Christopher B. Heward and Joseph Rogers and Andreas Papassotiropoulos and Eric M. Reiman and John S. Hardy and Dietrich A. Stephan},
  journal={The Journal of clinical psychiatry},
  year={2007},
  volume={68 4},
  pages={613-8}
}
OBJECTIVE While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in late-onset AD failed to identify this locus on chromosome 19. Recently developed methods for the simultaneous assessment of hundreds of thousands of single nucleotide polymorphisms (SNPs) promise to help more precisely identify loci that contribute to the risk of AD and other common multigenic conditions. We… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
212 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 212 extracted citations

Similar Papers

Loading similar papers…