A high-density poly(ethylene glycol) polymer brush for immobilization on glass-type surfaces.

@article{Piehler2000AHP,
  title={A high-density poly(ethylene glycol) polymer brush for immobilization on glass-type surfaces.},
  author={Jacob Piehler and Andreas Brecht and Ramūnas Valiokas and Bo Liedberg and G{\"u}nther Gauglitz},
  journal={Biosensors & bioelectronics},
  year={2000},
  volume={15 9-10},
  pages={473-81}
}
Label-free heterogeneous phase detection critically depends on the properties of the interfacial layer. We have obtained high-density monomolecular poly(ethylene glycol) (PEG) layers by solvent-free coupling of homo-bifunctional PEGs (2,000 g/mol) at 75 degrees C to silica surfaces silanized with glycidyloxipropyltrimethoxysilane (GOPTS). Characterization by ellipsometry and contact angles revealed that PEG layers up to 3.4 ng/mm2 with low roughness and flexibility were obtained. Specific and… CONTINUE READING