A high content screening assay to predict human drug-induced liver injury during drug discovery.

Abstract

INTRODUCTION Adverse drug reactions are a major cause for failures of drug development programs, drug withdrawals and use restrictions. Early hazard identification and diligent risk avoidance strategies are therefore essential. For drug-induced liver injury (DILI), this is difficult using conventional safety testing. To reduce the risk for DILI, drug… (More)
DOI: 10.1016/j.vascn.2013.08.001

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