A high-content screening assay for small-molecule modulators of oncogene-induced senescence.

Abstract

Cellular senescence is a state of stable cell growth arrest. Activation of oncogenes such as RAS in mammalian cells typically triggers cellular senescence. Oncogene-induced senescence (OIS) is an important tumor suppression mechanism, and suppression of OIS contributes to cell transformation. Oncogenes trigger senescence through a multitude of incompletely… (More)
DOI: 10.1177/1087057113491827

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@article{Bitler2013AHS, title={A high-content screening assay for small-molecule modulators of oncogene-induced senescence.}, author={Benjamin G. Bitler and Lauren S. Fink and Zhi Wei and J. R. Peterson and Rugang Zhang}, journal={Journal of biomolecular screening}, year={2013}, volume={18 9}, pages={1054-61} }