A high-cholesterol diet increases the association between caveolae and insulin receptors in rat liver.

@article{HahnObercyger2009AHD,
  title={A high-cholesterol diet increases the association between caveolae and insulin receptors in rat liver.},
  author={Michal Hahn-Obercyger and Lutz Graeve and Zecharia Madar},
  journal={Journal of lipid research},
  year={2009},
  volume={50 1},
  pages={98-107}
}
Caveolin-1, a component of caveolae, regulates signaling pathway compartmentalization by interacting with tyrosine (Tyr) kinase receptors and their substrates. Perturbations in caveolae lipid composition have been shown in vitro to displace proteins from lipid microdomains, thereby altering their functionality and subsequent downstream signaling. The role of caveolin-1 in insulin receptor (IR) signaling has been widely investigated in vitro mainly in 3T3-L1 adipocyte cells. However, in vivo… CONTINUE READING

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