A high antithymocyte globulin dose increases the risk of relapse after reduced intensity conditioning HSCT with unrelated donors.

@article{Remberger2013AHA,
  title={A high antithymocyte globulin dose increases the risk of relapse after reduced intensity conditioning HSCT with unrelated donors.},
  author={Mats Remberger and Olle Ringd{\'e}n and Hans H{\"a}gglund and B M Svahn and Per Ljungman and Michael Uhlin and J. -E. Mattsson},
  journal={Clinical transplantation},
  year={2013},
  volume={27 4},
  pages={E368-74}
}
The study included 110 consecutive patients with hematological malignancies receiving fludarabine-based reduced intensity conditioning (RIC) and hematopoietic stem cell transplantation (HSCT) from matched unrelated donors. The median age was 55 yr (range 11-68) and all but 15 patients received peripheral blood stem cell grafts. Antithymocyte globulin (ATG) (Thymoglobulin, Genzyme) at a total dose of 6 mg/kg (n = 66) or 8 mg/kg (n = 44) was given to all patients according to protocol. The ATG… CONTINUE READING
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