A high-affinity receptor for urokinase plasminogen activator on human keratinocytes: characterization and potential modulation during migration.

@article{McNeill1990AHR,
  title={A high-affinity receptor for urokinase plasminogen activator on human keratinocytes: characterization and potential modulation during migration.},
  author={H G McNeill and Pamela J. Jensen},
  journal={Cell regulation},
  year={1990},
  volume={1 11},
  pages={
          843-52
        }
}
Low passage cultures of normal human keratinocytes produce several components of the plasminogen activator/plasmin proteolytic cascade, including urokinase plasminogen activator (uPA), tissue plasminogen activator (tPA), and two specific inhibitors. Studies here presented demonstrate that these cells also contain a high-affinity (Kd = 3 x 10(-10) M) plasma membrane-binding site for uPA. High molecular weight uPA, either as the single-chain precursor or two-chain activated form, bound to the… CONTINUE READING
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Characterization of the cellular binding site for the urokinase type plasminogen activator

  • G. Fibbi, M. Ziche, L. Morbidelli, L. Magnelli, M. Del Rosso
  • J. Biol. Chem
  • 1989

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