A high affinity T cell receptor?

  title={A high affinity T cell receptor?},
  author={Saverio Alberti},
  journal={Immunology and cell biology},
  volume={74 3},
T cell receptors (TCR) have a low affinity for the MHC and the presented peptides (MHCpep). The low affinity of the TCR is crucial in T cell recognition and activation. Nevertheless, I propose that the TCR is perfectly capable of specifically binding MHCpep with high affinity. This hypothesis is supported by several data. Among them, the frequency of negatively selected immature T cells and of high affinity alloreactive T cells. Structural and functional analysis indicates that the TCR binding… CONTINUE READING