A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.

@article{Saito2014AHN,
  title={A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.},
  author={Norihiko Saito and Jun Fu and Siyuan Zheng and Jun Yao and Shuzhen Wang and Diane D. Liu and Ying Yuan and Erik P. Sulman and Frederick F. Lang and Howard Colman and Roel G W Verhaak and W. K. Alfred Yung and Dimpy Koul},
  journal={Stem cells},
  year={2014},
  volume={32 1},
  pages={301-12}
}
Genomic, transcriptional, and proteomic analyses of brain tumors reveal subtypes that differ in pathway activity, progression, and response to therapy. However, a number of small molecule inhibitors under development vary in strength of subset and pathway-specificity, with molecularly targeted experimental agents tending toward stronger specificity. The Notch signaling pathway is an evolutionarily conserved pathway that plays an important role in multiple cellular and developmental processes… CONTINUE READING

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