A hierarchy of Hu RNA binding proteins in developing and adult neurons.

@article{Okano1997AHO,
  title={A hierarchy of Hu RNA binding proteins in developing and adult neurons.},
  author={Hirotaka James Okano and Robert B Darnell},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 9},
  pages={3024-37}
}
The Hu proteins are a group of antigens targeted in an immune-mediated neurodegenerative disorder associated with cancer. We have cloned and characterized four members of the Hu gene family from mouse. We find that the Hu genes encode a large number of alternatively spliced transcripts to produce a series of related neuron-specific RNA binding proteins. Despite this complexity, we have discerned several ordered features of Hu expression. In the embryo, specific Hu genes are expressed in a… CONTINUE READING
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