A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth.

@article{Wang2007AHN,
  title={A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth.},
  author={Qianben Wang and Wei Li and Xiaole Shirley Liu and Jason S. Carroll and Olli A. J{\"a}nne and Erika Krasnickas Keeton and Arul M. Chinnaiyan and Kenneth J. Pienta and Myles Brown},
  journal={Molecular cell},
  year={2007},
  volume={27 3},
  pages={380-92}
}
Androgen receptor (AR) is a ligand-dependent transcription factor that plays a key role in prostate cancer. Little is known about the nature of AR cis-regulatory sites in the human genome. We have mapped the AR binding regions on two chromosomes in human prostate cancer cells by combining chromatin immunoprecipitation (ChIP) with tiled oligonucleotide microarrays. We find that the majority of AR binding regions contain noncanonical AR-responsive elements (AREs). Importantly, we identify a… CONTINUE READING
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