A hierarchical coherent-gene-group model for brain development.

  title={A hierarchical coherent-gene-group model for brain development.},
  author={Igor F. Tsigelny and Valentina L. Kouznetsova and Michael Baitaluk and J-P Changeux},
  journal={Genes, brain, and behavior},
  volume={12 2},
We have described a strategy to analyze the data available on brain genes expression, using the concept of coherent-gene groups controlled by transcription factors (TFs). A hierarchical model of gene-expression patterns during brain development was established that identified the genes assumed to behave as functionally coding. Analysis of the concerned signaling pathways and processes showed distinct temporal gene-expression patterns in relation with neurogenesis/synaptogenesis. We identified… CONTINUE READING
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