A hierarchical approach to aligning collinear regions of genomes

@article{Roytberg2002AHA,
  title={A hierarchical approach to aligning collinear regions of genomes},
  author={Mikhail A. Roytberg and Aleksey Y. Ogurtsov and Svetlana A. Shabalina and Alexey S. Kondrashov},
  journal={Bioinformatics},
  year={2002},
  volume={18 12},
  pages={1673-80}
}
MOTIVATION As a first approximation, similarity between two long orthologous regions of genomes can be represented by a chain of local similarities. Within such a chain, pairs of successive similarities are collinear (non-conflicting), i.e. segments involved in the nth similarity precede in both sequences segments involved in the (n+1)th similarity. However, when all similarities between two long sequences are considered, usually there are many conflicts between them. Although some conflicts… CONTINUE READING

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