A hidden region in the third variable domain of HIV-1 IIIB gp120 identified by a monoclonal antibody.

@article{Laman1993AHR,
  title={A hidden region in the third variable domain of HIV-1 IIIB gp120 identified by a monoclonal antibody.},
  author={Jon D Laman and M. H. M. Schellekens and George K. Lewis and John P. Moore and Thomas J. Matthews and Johannes P Langedijk and R. H. Meloen and Wim J. A. Boersma and E. P. Claassen},
  journal={AIDS research and human retroviruses},
  year={1993},
  volume={9 7},
  pages={605-12}
}
The third variable domain (V3 domain) of HIV-1 gp120 is involved in virus neutralization by antibody, in determination of cell tropism, and in syncytium-inducing/non-syncytium-inducing capacity. Antibodies are highly specific tools to delineate the role of different V3 amino acid sequences in these processes, and to dissect events occurring during synthesis of gp120/160, gp120-CD4 interaction, cellular infection, and syncytium formation. We describe here an IgG1 murine monoclonal antibody (MAb… CONTINUE READING