A hexameric phosphorothioate oligonucleotide telomerase inhibitor arrests growth of Burkitt's lymphoma cells in vitro and in vivo.

@article{Mata1997AHP,
  title={A hexameric phosphorothioate oligonucleotide telomerase inhibitor arrests growth of Burkitt's lymphoma cells in vitro and in vivo.},
  author={John Enrique Mata and Shantaram S. Joshi and B Palen and SamuelJ. Pirruccello and John I. Jackson and Nahel Elias and Todd J Page and K L Medlin and Patrick L. Iversen},
  journal={Toxicology and applied pharmacology},
  year={1997},
  volume={144 1},
  pages={
          189-97
        }
}
A phosphorothioate oligonucleotide (PS-ODN) with sequence identical to the repeat sequence of the mammalian telomere, 5'-d(TTAGGG)-3', was incubated with a Burkitt's lymphoma-derived (OMA-BL1) cell line. This hexanucleotide inhibits telomerase activity in cell lysates, lengthens cell doubling time, and induces apoptosis. Concatenated repeats (12-, 18-, and 24-mers) of the 5'-d(TTAGGG)-3' motif induce similar cellular responses. Scrambled sequences do not efficiently inhibit telomerase activity… CONTINUE READING
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