A heterotrimeric G protein of the Gi family is required for cAMP-triggered trafficking of aquaporin 2 in kidney epithelial cells.

@article{Valenti1998AHG,
  title={A heterotrimeric G protein of the Gi family is required for cAMP-triggered trafficking of aquaporin 2 in kidney epithelial cells.},
  author={Giovanna Valenti and Giuseppe Procino and U Liebenhoff and Antonio Frigeri and Pier Alberto Benedetti and Gudrun Ahnert-Hilger and B. Meinecke N{\"u}rnberg and Maria Svelto and Walter Rosenthal},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 35},
  pages={22627-34}
}
Vasopressin is the key regulator of water homeostasis in vertebrates. Central to its antidiuretic action in mammals is the redistribution of the water channel aquaporin 2 (AQP2) from intracellular vesicles to the apical membrane of kidney epithelial cells, an event initiated by an increase in cAMP and activation of protein kinase A. The subsequent steps of the signaling cascade are not known. To identify proteins involved in the AQP2 shuttle we exploited a recently developed cell line (CD8… CONTINUE READING