A heterogeneous population of alpha 1 adrenergic receptors mediates contraction of human corpus cavernosum smooth muscle to norepinephrine.

@article{Traish1995AHP,
  title={A heterogeneous population of alpha 1 adrenergic receptors mediates contraction of human corpus cavernosum smooth muscle to norepinephrine.},
  author={Abdulmaged M Traish and N Netsuwan and Jennifer Daley and H Padman-Nathan and Irwin S. Goldstein and I{\~n}igo S{\'a}enz de Tejada},
  journal={The Journal of urology},
  year={1995},
  volume={153 1},
  pages={222-7}
}
In this study we investigated the physiological properties and binding characteristics of alpha-1 adrenergic receptor (alpha 1-AR) in human corpus cavernosum (HCC) in order to identify alpha 1-AR subtypes at the functional protein level. Exposure of tissue strips to norepinephrine (NE) caused concentration-dependent contractions that were partially and noncompetitively inhibited by 10 to 100 microM. of chloroethylclonidine (CEC), an alkylating agent that specifically and irreversibly… CONTINUE READING

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