A heterogeneous "resting" pool of synaptic vesicles that is dynamically interchanged across boutons in mammalian CNS synapses.

@article{FernndezAlfonso2008AH,
  title={A heterogeneous "resting" pool of synaptic vesicles that is dynamically interchanged across boutons in mammalian CNS synapses.},
  author={Tom{\'a}s Fern{\'a}ndez-Alfonso and Timothy A Ryan},
  journal={Brain cell biology},
  year={2008},
  volume={36 1-4},
  pages={87-100}
}
Using pHluorin-tagged synaptic vesicle proteins we have examined the partitioning of these probes into recycling and nonrecycling pools at hippocampal nerve terminals in cell culture. Our studies show that for three of the major synaptic vesicle components, vGlut-1, VAMP-2, and Synaptotagmin I, approximately 50-60% of the tagged protein appears in a recycling pool that responds readily to sustained action potential stimulation by mobilizing and fusing with the plasma membrane, while the… CONTINUE READING

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