A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes
@article{Sase2016AHC, title={A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes}, author={Ajinkya S. Sase and Y. D. Aher and Sivaprakasam R Saroja and Minu Karthika Ganesan and Sunetra Sase and Marion Holy and Harald Höger and Vasiliy A. Bakulev and Gerhard F. Ecker and Thierry Langer and Harald H. Sitte and Johann Jakob Leban and Gert Lubec}, journal={Neuropharmacology}, year={2016}, volume={102}, pages={186-196} }
14 Citations
A novel heterocyclic compound targeting the dopamine transporter improves performance in the radial arm maze and modulates dopamine receptors D1-D3
- Biology, ChemistryBehavioural Brain Research
- 2016
A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat
- Biology, PsychologyBehavioural Brain Research
- 2017
A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval
- BiologyBehavioural Brain Research
- 2018
Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors.
- Biology, ChemistryJournal of medicinal chemistry
- 2017
A series of compounds were showing higher activities on the DAT and a higher selectivity toward DAT versus serotonin and norepinephrine transporters than modafinil and the absence of neurotoxicity of a representative analogue may encourage further preclinical studies of the above-mentioned compounds.
CE-123, a novel dopamine transporter inhibitor, attenuates locomotor hyperactivity and improves cognitive functions in rat model of fetal alcohol spectrum disorders
- Biology, PsychologyBehavioural Brain Research
- 2021
The Novel Analogue of Modafinil CE-158 Protects Social Memory against Interference and Triggers the Release of Dopamine in the Nucleus Accumbens of Mice
- Biology, PsychologyBiomolecules
- 2022
Previous studies have shown that atypical dopamine-transporter-inhibitors such as modafinil and its analogues modify behavioral and cognitive functions in rodents. Here, we tested potential…
R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity
- Biology, PsychologyPloS one
- 2017
The results support the notion that LTP-like synaptic plasticity processes could be one of the factors contributing to the cognitive enhancing effects of spatial memory traces and D1R may play an important regulatory role in these processes.
In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling-related proteins and enhances methamphetamine addiction in male rats
- BiologyBrain Structure and Function
- 2020
It is indicated that reduced D1R expression in the DS increases vulnerability to methamphetamine addiction-like behavior, and this is accompanied by striatal alterations in the expression of DAT and D1r signaling proteins and is independent of the subcellular localization of these proteins.
Evaluating Working Memory on a T-maze in Male Rats.
- Biology, PsychologyBio-protocol
- 2018
This work presents a training protocol for evaluating the underlying mechanisms that lead to the development of spatial working memory in rats using a T-maze, and it can be used to get high temporal resolution.
Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation
- BiologyScientific Reports
- 2020
The studies provide evidence for a tumor suppressor role of GLS2 in certain types of cancer and imply that G LS2 can be regarded as a highly mobile and multilocalizing protein translocated to both mitochondria and nuclei.
References
SHOWING 1-10 OF 79 REFERENCES
Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism
- BiologyNeuropharmacology
- 2014
Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive ‘Bath Salts’ Products
- BiologyNeuropsychopharmacology
- 2013
The data show that MDPV is a monoamine transporter blocker with increased potency and selectivity for catecholamines when compared with cocaine, and may provide a mechanism to explain the adverse effects observed in humans taking high doses of ‘bath salts’ preparations.
A selective dopamine reuptake inhibitor improves prefrontal cortex-dependent cognitive function: Potential relevance to attention deficit hyperactivity disorder
- Psychology, BiologyNeuropharmacology
- 2013
Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats
- Biology, PsychologyNeuroscience
- 1999
Regulation of Dopamine Transporter Function and Cell Surface Expression by D3 Dopamine Receptors*
- Biology, ChemistryJournal of Biological Chemistry
- 2007
It is demonstrated that D3 receptors regulate dopamine transporter function and a novel mechanism by which D3 receptor regulate extracellular dopamine concentrations is identified.
The N Terminus of Monoamine Transporters Is a Lever Required for the Action of Amphetamines*
- BiologyThe Journal of Biological Chemistry
- 2010
It is concluded that the N terminus of monoamine transporters acts as a lever that sustains reverse transport.
Performance- and task-dependent effects of the dopamine D1/D5 receptor agonist SKF 38393 on learning and memory in the rat.
- Psychology, BiologyEuropean journal of pharmacology
- 2007
Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.
- Psychology, BiologyThe Journal of pharmacology and experimental therapeutics
- 1997
The selective dopamine D1 receptor full agonists A77636 and SKF81297 were examined in aged monkeys for effects on the working memory functions of the PFC and the improvement and impairment in performance were reversed by pretreatment with the D1 receptors antagonist, SCH23390.
Dopamine transporter as target for drug development of cocaine dependence medications.
- Biology, ChemistryEuropean journal of pharmacology
- 2003
Characterization and localization of [125I]RTI-121 binding sites in human striatum and medial temporal lobe.
- BiologyThe Journal of pharmacology and experimental therapeutics
- 1995
The kinetic, saturation, competition and autoradiographic experiments demonstrated that [125I]RTI-121 can be used to identify DAT binding sites and to assess their functional state in post mortem human brain samples.