A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes

@article{Sase2016AHC,
  title={A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes},
  author={Ajinkya S. Sase and Y. D. Aher and Sivaprakasam R. Saroja and Minu Karthika Ganesan and Sunetra Sase and Marion Holy and Harald Höger and Vasiliy A. Bakulev and Gerhard F. Ecker and Thierry Langer and Harald H. Sitte and Johann Jakob Leban and Gert Lubec},
  journal={Neuropharmacology},
  year={2016},
  volume={102},
  pages={186-196}
}
A series of compounds have been reported to enhance memory via the DA system and herein a heterocyclic compound was tested for working memory (WM) enhancement. 2-((benzhydrylsulfinyl)methyl)thiazole (CE-103) was synthesized in a six-step synthesis. Binding of CE-103 to the dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters and dopamine reuptake inhibition was tested as well as blood brain permeation and a screen for GPCR targets. 60 male Sprague Dawley rats were divided into… Expand
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