A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes

  title={A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes},
  author={Ajinkya S. Sase and Y. D. Aher and Sivaprakasam R Saroja and Minu Karthika Ganesan and Sunetra Sase and Marion Holy and Harald Höger and Vasiliy A. Bakulev and Gerhard F. Ecker and Thierry Langer and Harald H. Sitte and Johann Jakob Leban and Gert Lubec},

Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors.

A series of compounds were showing higher activities on the DAT and a higher selectivity toward DAT versus serotonin and norepinephrine transporters than modafinil and the absence of neurotoxicity of a representative analogue may encourage further preclinical studies of the above-mentioned compounds.

The Novel Analogue of Modafinil CE-158 Protects Social Memory against Interference and Triggers the Release of Dopamine in the Nucleus Accumbens of Mice

Previous studies have shown that atypical dopamine-transporter-inhibitors such as modafinil and its analogues modify behavioral and cognitive functions in rodents. Here, we tested potential

R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity

The results support the notion that LTP-like synaptic plasticity processes could be one of the factors contributing to the cognitive enhancing effects of spatial memory traces and D1R may play an important regulatory role in these processes.

In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling-related proteins and enhances methamphetamine addiction in male rats

It is indicated that reduced D1R expression in the DS increases vulnerability to methamphetamine addiction-like behavior, and this is accompanied by striatal alterations in the expression of DAT and D1r signaling proteins and is independent of the subcellular localization of these proteins.

Evaluating Working Memory on a T-maze in Male Rats.

This work presents a training protocol for evaluating the underlying mechanisms that lead to the development of spatial working memory in rats using a T-maze, and it can be used to get high temporal resolution.

Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation

The studies provide evidence for a tumor suppressor role of GLS2 in certain types of cancer and imply that G LS2 can be regarded as a highly mobile and multilocalizing protein translocated to both mitochondria and nuclei.



Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive ‘Bath Salts’ Products

The data show that MDPV is a monoamine transporter blocker with increased potency and selectivity for catecholamines when compared with cocaine, and may provide a mechanism to explain the adverse effects observed in humans taking high doses of ‘bath salts’ preparations.

Regulation of Dopamine Transporter Function and Cell Surface Expression by D3 Dopamine Receptors*

It is demonstrated that D3 receptors regulate dopamine transporter function and a novel mechanism by which D3 receptor regulate extracellular dopamine concentrations is identified.

The N Terminus of Monoamine Transporters Is a Lever Required for the Action of Amphetamines*

It is concluded that the N terminus of monoamine transporters acts as a lever that sustains reverse transport.

Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.

  • J. CaiA. Arnsten
  • Psychology, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1997
The selective dopamine D1 receptor full agonists A77636 and SKF81297 were examined in aged monkeys for effects on the working memory functions of the PFC and the improvement and impairment in performance were reversed by pretreatment with the D1 receptors antagonist, SCH23390.

Characterization and localization of [125I]RTI-121 binding sites in human striatum and medial temporal lobe.

The kinetic, saturation, competition and autoradiographic experiments demonstrated that [125I]RTI-121 can be used to identify DAT binding sites and to assess their functional state in post mortem human brain samples.