A heretofore undisclosed crux of Eosinophilia-Myalgia Syndrome: compromised histamine degradation

@article{Smith2005AHU,
  title={A heretofore undisclosed crux of Eosinophilia-Myalgia Syndrome: compromised histamine degradation},
  author={M. J. Smith and Reginald H. Garrett},
  journal={Inflammation Research},
  year={2005},
  volume={54},
  pages={435-450}
}
Abstract.In contrast to early epidemiological evidence offering links between eosinophilia-myalgia syndrome (EMS) and microimpurities of L-tryptophan-containing dietary supplements (LTCDS), this account shows why reliance on a finite impurity from one manufacturer is both unnecessary and insufficient to explain the etiology of EMS. Excessive histamine activity has induced blood eosinophilia and myalgia (Greek: mys, muscle + algos, pain). Termination of the multiple actions of histamine is… 
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Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies
TLDR
With respect to offi cial cases of Eosinophilia-Myalgia Syndrome (EMS), reliance on a fi nite impurity in L-tryptophan-containing dietary supplements (LTCDS) is insuffi cient and unnecessary to explain its multiple causes.
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