A hereditary immunoglobulin A abnormality: absence of light-heavy-chain assembly. Study of immunoglobulin synthesis in tonsillar cells.


A new immunoglobulin A abnormality, absence of assembly of alpha-chain and light-chain, was found in an adult female suffering from recurrent upper respiratory infection and tonsillitis since childhood, but otherwise healthy. The IgA abnormality was manifest in her serum by the presence of free alpha-chains, in her saliva by the presence of alpha-chains… (More)


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