A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals

@inproceedings{Uno2015AHA,
  title={A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals},
  author={Kenji Uno and Tetsuya Yamada and Yasushi Ishigaki and Junta Imai and Yutaka Hasegawa and Shojiro Sawada and Keizō Kaneko and Hiraku Ono and Tomoichiro Asano and Yoshitomo Oka and Hideki Katagiri},
  booktitle={Nature communications},
  year={2015}
}
Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signalling modulates systemic lipid metabolism via a mechanism involving neuronal inter-tissue communication. Hepatic expression of an AA transporter, SNAT2, activates the mTORC1/S6K pathway, and markedly… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

The Tryptophan Pathway Targeting Antioxidant Capacity in the Placenta

  • Oxidative medicine and cellular longevity
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.

Supplementary Table 2. Primers used in quantitative RT-PCR

  • Supplementary Table 2. Primers used in quantitative RT-PCR