A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF

@article{Higashiyama1991AHG,
  title={A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF},
  author={Shigeki Higashiyama and Jacob Abraham and J. Miller and JC Fiddes and Michael Klagsbrun},
  journal={Science},
  year={1991},
  volume={251},
  pages={936 - 939}
}
Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates that the mitogen is a new member of the epidermal growth factor (EGF) family. This heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma cells and smooth muscle cells, but is a far more potent mitogen… 

Heparin-binding EGF-like growth factor.

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This review describes the primary structure of HB-EGF, as well as its processing, and summarizes its expression patterns, receptor-mediated signaling, and role in several important biological systems.

Heparin-binding epidermal growth factor-like growth factor regulates fibroblast growth factor-2 expression in aortic smooth muscle cells.

TLDR
It is reported that HB-EGF treatment of serum-starved at aortic SMCs can induce fibroblast growth factor (FGF)-2 (basic FGF) gene expression but not FGF-1 (acidic FGF).

[Heparin-binding EGF-like growth factor (HB-EGF)].

TLDR
The interaction of HB-EGF, via its heparin-binding domain, with cell surface heparan sulfate proteoglycan is essential for its optimal binding to the EGF receptor on bovine aortic smooth muscle cells, and hence for the optimal ability to stimulate migration.

Heparin-binding EGF-like growth factor is a mitogen for rat alveolar type II cells.

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It is demonstrated that heparin-binding EGF-like growth factor is a mitogen for rat alveolar type II cells but appears to show species-specific differences with regard to its production by macrophages.

Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes.

TLDR
It is suggested that epiregulin plays important roles in regulating the growth of epithelial cells and fibroblasts by binding to receptors for EGF-related ligands.
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