A hemoglobin based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus Hetastarch (HEX) in an uncontrolled liver injury hemorrhagic shock swine model with delayed evacuation.

@article{Gurney2004AHB,
  title={A hemoglobin based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus Hetastarch (HEX) in an uncontrolled liver injury hemorrhagic shock swine model with delayed evacuation.},
  author={Jennifer Gurney and Nora B Philbin and Jennifer S Rice and Françoise G. Arnaud and Feng Dong and Meghan C Wulster-Radcliffe and L Bruce Pearce and Lewis Kaplan and Richard McCarron and Daniel Freilich},
  journal={The Journal of trauma},
  year={2004},
  volume={57 4},
  pages={726-38}
}
BACKGROUND As HBOC-201 improves outcome in animals with hemorrhagic shock (HS), we compared HBOC-201 and HEX (used by U.S. military special operations forces) in a swine model of delayed evacuation and uncontrolled HS. METHODS Twenty-four Yucatan pigs underwent a grade III liver injury and were resuscitated with HBOC-201, HEX, or no fluid (NON). Additional infusions were given for hypotension or tachycardia. After 4 hours, the liver was repaired; IV fluids and blood transfusions were… CONTINUE READING