A helper virus-free packaging system for recombinant adeno-associated virus vectors.

@article{Collaco1999AHV,
  title={A helper virus-free packaging system for recombinant adeno-associated virus vectors.},
  author={Roy F Collaco and Xiaoying Cao and J. P. Trempe},
  journal={Gene},
  year={1999},
  volume={238 2},
  pages={397-405}
}
Adeno-associated virus (AAV) is a human parvovirus that is currently receiving widespread attention for its potential use as a gene therapy vector. Construction of the recombinant AAV vector (rAAV) involves replacing most of the viral genome with a transgene of interest and then packaging this recombinant genome into an infectious virion. Most current protocols for generating rAAV entail the co-transfection of a vector plasmid and a packaging plasmid that expresses the viral replication and… CONTINUE READING

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