A helper-independent adenovirus vector with E1, E3, and fiber deleted: structure and infectivity of fiberless particles.

@article{Seggern1999AHA,
  title={A helper-independent adenovirus vector with E1, E3, and fiber deleted: structure and infectivity of fiberless particles.},
  author={Dan J von Seggern and Charles Y Chiu and Shonna Kaye Fleck and Phoebe L. Stewart and Glen R. Nemerow},
  journal={Journal of virology},
  year={1999},
  volume={73 2},
  pages={1601-8}
}
The adenovirus (Ad) fiber protein largely determines viral tropism through interaction with specific cell surface receptors. This molecule may also be involved in virion assembly or maturation, as some previously characterized fiber mutants were defective for processing of viral structural proteins. We previously described packaging cell lines that express Ad type 5 (Ad5) fiber and can complement the temperature-sensitive Ad fiber mutant H5ts142. We have now used these packaging cells to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…