A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel.

@article{Kienker1994AHM,
  title={A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel.},
  author={Paul K. Kienker and William F. DeGrado and James D. Lear},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 11},
  pages={4859-63}
}
We are designing simple peptide ion channels as model systems for the study of the physical principles controlling conduction through ion-channel proteins. Here we report on an uncharged peptide, Ac-(Leu-Ser-Ser-Leu-Leu-Ser-Leu)3-CONH2, designed to form an aggregate of parallel, amphiphilic, membrane-spanning alpha-helices around a central water-filled pore. This peptide in planar lipid bilayers forms ion channels that show single-channel current rectification in symmetric 1 M KCl. The current… CONTINUE READING

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