A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells.

@article{Brayden2014AHM,
  title={A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells.},
  author={David J Brayden and John Gleeson and Edwin G Walsh},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2014},
  volume={88 3},
  pages={830-39}
}
There is debate over the narrow safety margin of many oral permeation enhancers. The sodium salts of medium chain fatty acids (MCFAs) are components of selected oral peptide formulations being assessed in advanced clinical studies. The aim of the study was to examine the effects of the C8-C12 series on filter-grown Caco-2 monolayers and cells grown on 96 well plates in order to dissect the relationship between paracellular permeability enhancement (Papp of [14C]mannitol, reduction in TEER… CONTINUE READING

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