A hapten-specific chimaeric IgE antibody with human physiological effector function.

@article{Neuberger1985AHC,
  title={A hapten-specific chimaeric IgE antibody with human physiological effector function.},
  author={Michael Neuberger and Gareth T. Williams and Elizabeth B Mitchell and S S Jouhal and John G. Flanagan and Terence H Rabbitts},
  journal={Nature},
  year={1985},
  volume={314 6008},
  pages={268-70}
}
Immunoglobulin E (IgE) has a central role in allergic reactions although it rarely exceeds 5 micrograms ml-1 even in the serum of severely allergic individuals. Both mast cells and basophils possess receptors which bind the Fc portion of IgE with high affinity; crosslinking of membrane-bound IgE by allergen results in degranulation of the cell and release of a variety of pharmacologically active mediator including histamine. Myeloma IgE has been successfully used to block the skin sensitizing… CONTINUE READING
46 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

Similar Papers

Loading similar papers…