A haplotype of the CYP4F2 gene is associated with cerebral infarction in Japanese men.

@article{Fu2008AHO,
  title={A haplotype of the CYP4F2 gene is associated with cerebral infarction in Japanese men.},
  author={Zhen-Yan Fu and Tomohiro Nakayama and Naoyuki Sato and Yoichi Izumi and Yuji Kasamaki and Atsushi Shindo and Masakatsu Ohta and Masayoshi Soma and Noriko Aoi and Mikano Sato and Koichi Matsumoto and Yukio Ozawa and Yi-Tong Ma},
  journal={American journal of hypertension},
  year={2008},
  volume={21 11},
  pages={
          1216-23
        }
}
BACKGROUND CYP4F2, a member of the cytochrome P450 family, acts mainly as an enzyme and is involved not only in the metabolism of leukotriene B4, but also in that of arachidonic acid. It converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite involved in the regulation of the vascular tone in the brain. The aim of this study was to assess the association between the human CYP4F2 gene and cerebral infarction (CI), using a haplotype-based case-control study with… Expand
CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population
TLDR
The GG genotype and G allele were associated with ischemic stroke in the male Northern Chinese Han population and revealed the significance of the rs2108622 in males after adjustment for confounding factors. Expand
A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.
This study assessed associations between the CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study of 234 MI patients and 248 controls genotyped for 5Expand
Association of 1347 G/A cytochrome P450 4F2 (CYP4F2) gene variant with hypertension and stroke
TLDR
It is suggested that 1347A allele of CYP4F2 gene is an important risk factor for hypertension and ischemic stroke. Expand
Interaction among CYP2C8, EPHX2, and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke in Chinese Populations.
TLDR
The combinatorial analysis used in this study may be helpful to elucidate complex genetic risk factors for IS. Expand
Peripheral and central augmentation indexes in relation to the CYP4F2 polymorphisms in Chinese
TLDR
The CYP4F2 V433M polymorphism is associated with the size of arterial wave reflections in male Chinese, or individuals with a faster pulse rate, as measured by augmentation indexes (AIx) in Chinese. Expand
Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?
TLDR
This finding indicates that altered 20-HETE bioactivity underlay the excess of hypertension and associated vascular events observed in men with respect to women and is consistent with the results from experimental models. Expand
Interaction Between CYP4F2 rs2108622 and CPY4A11 rs9333025 Variants Is Significantly Correlated with Susceptibility to Ischemic Stroke and 20-Hydroxyeicosatetraenoic Acid Level.
TLDR
YP4A1l rs9333025 GG and CYP4F2 rs2108622 GG two-loci interaction significantly increases the risk for IS and an elevated 20-HETE level. Expand
Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls.
TLDR
The present study highlights the elevation in CYP450AAM and oxidative stress in acute ischaemic stroke patients and the effect this has on long-term clinical outcome or whether this can be modified by treatment is warranted. Expand
Cytochrome P450 family 4 subfamily F member 2 (CYP4F2) rs1558139, rs2108622 polymorphisms and susceptibility to several cardiovascular and cerebrovascular diseases
TLDR
C/T genotype of CYP4AF2 rs1558139 may be linked to the decreased risk of hypertension in the male patients of Asian populations, while CYP 4F2 rs2108622 is likely associated with reduced susceptibility to CAD. Expand
Cytochrome P 450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls
CYP450AAM [arachidonic acid metabolites of the CYP450 (cytochrome P450) enzyme system] have a range of biological functions. CYP450AAM are involved in the pathogenesis of hypertension, renal functionExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men
TLDR
Essential hypertension is associated with the TC + TT genotype of rs1126742 in the human CYP4A11 gene and the A-T-G haplotype appears a useful genetic marker of essential hypertension in Japanese men. Expand
Functional polymorphism in human CYP4F2 decreases 20-HETE production.
TLDR
These findings are the first to identify a functional variant in the human CYP4F2 gene that alters the production of 20-HETE and have no effect on the omega-hydroxylation of LTB(4). Expand
Cytochrome P450 1A1 (CYP1A1) T6325C polymorphism might modulate essential hypertension-associated stroke risk.
  • V. Lança, P. Alcântara, J. Braz-Nogueira, M. Bicho
  • Medicine
  • Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology
  • 2004
TLDR
The results suggest a relationship between CYP1A1 activity and incidence of stroke in patients with essential hypertension, but no conclusion can be drawn regarding an association withessential hypertension. Expand
An association study in essential hypertension using functional polymorphisms in lymphotoxin-alpha gene.
TLDR
Polymorphisms of the LTA gene were not associated with EH, and this finding suggests differences in genetic backgrounds between EH and MI. Expand
Association between the calcitonin-related peptide alpha (CALCA) gene and essential hypertension in Japanese subjects.
TLDR
A novel 2-bp microdeletion polymorphism was discovered in the CALCA gene and could be the susceptibility gene for EH, based on the results of the haplotype-based case control study. Expand
Association study of calcitonin-receptor-like receptor gene in essential hypertension.
TLDR
The findings suggest that rs696574 can be used as a genetic marker of EH in women, and there was no significant difference in overall distribution of genotypes or alleles of any of the SNP between the EH and NT groups. Expand
Association study between C-reactive protein genes and ischemic stroke in Japanese subjects.
TLDR
The rs1800947 SNP and the C-C-C haplotype in the CRP gene appear to be prognostic markers of ischemic stroke and this polymorphism could be a useful genetic marker. Expand
Cytochrome P450 enzymes: central players in cardiovascular health and disease.
TLDR
A link between CYP expression and activity and CVD, such as hypertension, coronary artery disease, myocardial infarction, heart failure, stroke, and cardiomyopathy and arrhythmias, has been established and the evidence for the involvement of CYP in CVD is numerous. Expand
Down-regulation of astroglial CYP2C, glucocorticoid receptor and constitutive androstane receptor genes in response to cocaine in human U373 MG astrocytoma cells.
TLDR
Findings represent a possible molecular mechanism involved in the cerebrovascular risk associated with cocaine abuse and implicates various specific receptors including glucocorticoid receptor (GR) and constitutive androstane receptor (CAR). Expand
Formation of 20-Hydroxyeicosatetraenoic Acid, a Vasoactive and Natriuretic Eicosanoid, in Human Kidney
TLDR
CYP4F2 and CYP4A11 underlie conversion of AA to 20-HETE, a natriuretic and vasoactive eicosanoid, in human kidney, and considering their proximal tubular localization, these P450 enzymes may partake in pivotal renal functions, including the regulation of salt and water balance, and arterial blood pressure itself. Expand
...
1
2
3
4
...