A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men

  title={A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men},
  author={Z. Fu and T. Nakayama and N. Sato and Y. Izumi and Y. Kasamaki and A. Shindo and Masakatsu Ohta and M. Soma and N. Aoi and M. Sato and Y. Ozawa and Yi-Tong Ma},
  journal={Journal of Hypertension},
  • Z. Fu, T. Nakayama, +9 authors Yi-Tong Ma
  • Published 2008
  • Biology, Medicine
  • Journal of Hypertension
  • Objective CYP4A11, a member of the cytochrome P450 family, acts mainly as an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in blood pressure regulation in humans. Disruption of the murine cyp4a14 and cyp4a10 genes, homologues of human CYP4A11, was reported recently to cause hypertension. The gene-disrupted male mice had higher blood pressure than the gene-disrupted female mice. The present study aimed to assess the association between the human… CONTINUE READING
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