A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk.

@article{Freedman2005AHC,
  title={A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk.},
  author={Matthew L. Freedman and Kathryn L. Penney and Daniel O. Stram and Stephanie Riley and Roberta Mckean-Cowdin and Lo{\"i}c Le Marchand and David Altshuler and Christopher A. Haiman},
  journal={Cancer research},
  year={2005},
  volume={65 16},
  pages={7516-22}
}
Rare, highly penetrant germ line mutations in BRCA1 strongly predispose women to a familial form of breast and ovarian cancer. Whether common variants (either coding or noncoding) at this locus contribute to the more common form of the disease is not yet known. We tested common variation across the BRCA1 locus in African American, Native Hawaiian, Japanese, Latino, and White women in the Multiethnic Cohort Study. Specifically, 28 single nucleotide polymorphisms (SNPs) spanning the BRCA1 gene… CONTINUE READING