A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.

@article{ZavalaRuiz2004AHT,
  title={A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.},
  author={Zarixia Zavala-Ruiz and Iwona Strug and Bruce D. Walker and Phillip J Norris and Lawrence J Stern},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 36},
  pages={13279-84}
}
T cells generally recognize peptide antigens bound to MHC proteins through contacts with residues found within or immediately flanking the seven- to nine-residue sequence accommodated in the MHC peptide-binding groove. However, some T cells require peptide residues outside this region for activation, the structural basis for which is unknown. Here, we have investigated a HIV Gag-specific T cell clone that requires an unusually long peptide antigen for activation. The crystal structure of a… CONTINUE READING

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