A haemolytic syndrome associated with the complete absence of red cell membrane protein 4.2 in two Tunisian siblings.

@article{Ghanem1990AHS,
  title={A haemolytic syndrome associated with the complete absence of red cell membrane protein 4.2 in two Tunisian siblings.},
  author={A Ghanem and Brittany Pothier and Jo{\"e}lle Mar{\'e}chal and M. T. Ducluzeau and Laurette Morl{\'e} and Nicole Alloisio and C. P. De Feo and Abdeladhim Ben Abdeladhim and Sladdehine Fattoum and Jean Delaunay},
  journal={British journal of haematology},
  year={1990},
  volume={75 3},
  pages={414-20}
}
We report on the complete absence of protein 4.2 in two Tunisian siblings. The propositus presented with a haemolytic anaemia that evolved in an intermittent fashion until she was cured by splenectomy. Her red cells had a normal morphology, as well as normal deformability upon osmotic gradient ektacytometry. SDS-polyacrylamide gel electrophoresis failed to reveal any protein 4.2. Using anti-protein 4.2 polyclonal antibodies. Western blots were also unable to detect protein 4.2. Preparation of… CONTINUE READING

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